Spontaneous remission of agnogenic myeloid metaplasia in a splenectomized patient: a case report with erythrokinetic studies.

A 67-year-old woman with agnogenic myeloid metaplasia, who underwent splenectomy 1 year after the diagnosis, experienced spontaneous hematologic remission 6 years after splenectomy. Ten months before her anemia improved, peripheral leukocytes no longer showed a shift to the left and peripheral erythroblasts had disappeared. Sequential erythrokinetic studies revealed ineffective erythropoiesis with mild hemolysis and expansion of marrow activity in the tibia and femur but no erythropoiesis in the sacral or vertebral marrow.