John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.
J Biomech. 2011 Jan 11;44(2):244-7. doi: 10.1016/j.jbiomech.2010.10.013. Epub 2010 Nov 4.
Since 2005 reports have been published describing unusual femoral shaft fractures primarily in postmenopausal women treated for prolonged periods with a bisphosphonate drug for osteoporosis. In some patients pain develops in the femur prior to a completed fracture. Bilateral fractures have occurred in some patients. It is unclear whether oversuppression of bone cell activity is a major factor in the pathogenesis of the fractures, or whether these are a rare manifestation of the underlying bone disease. Such fractures do occur in other metabolic bone disorders in which there are marked abnormalities of bone structure.
自 2005 年以来，已有文献报道了一些不寻常的股骨骨干骨折，这些骨折主要发生在接受双膦酸盐类药物治疗骨质疏松症且治疗时间较长的绝经后妇女中。在一些患者中，在完全骨折之前，股骨会出现疼痛。一些患者发生了双侧骨折。目前尚不清楚骨细胞活性过度抑制是否是骨折发病机制中的一个主要因素，或者这些骨折是否是潜在骨病的罕见表现。在其他代谢性骨疾病中也会发生这种骨折，这些疾病的骨结构存在明显异常。
