地中海地区患有高血铁蛋白症和糖尿病的男性的铁过载水平并不高于没有糖尿病的患者。
Men with hyperferritinemia and diabetes in the Mediterranean area do not have a higher iron overload than those without diabetes.
机构信息
Hospital of Sabadell, Corporació Sanitària i Institut Universitari Parc Taulí (UAB), Sabadell, Spain.
出版信息
Diabetes Res Clin Pract. 2011 Feb;91(2):e33-6. doi: 10.1016/j.diabres.2010.10.003. Epub 2010 Nov 4.
AIM
To assess the role of iron overload in type 2 diabetic men with hyperferritinemia.
METHODS
150 men were recruited from a genetic screening programme for hereditary hemocromatosis (HH) and were tested for type 2 diabetes, other components of the metabolic syndrome, beta cell function (BCF), insulin sensitivity, high-sensitivity C-reactive protein and iron overload.
RESULTS
Fifty-one men had type 2 diabetes. They were older (p=0.017) and 99 had lower BCF (p<0.001) than non-diabetic men. None of the iron overload indexes was associated with diabetes.
CONCLUSIONS
Our findings dispute a role of iron overload in the pathogenesis of type 2 diabetes.
目的
评估铁过载在伴有高血铁蛋白的 2 型糖尿病男性中的作用。
方法
从遗传性血色病（HH）遗传筛查计划中招募了 150 名男性，并对其进行了 2 型糖尿病、代谢综合征的其他成分、β细胞功能（BCF）、胰岛素敏感性、高敏 C 反应蛋白和铁过载的检测。
结果
51 名男性患有 2 型糖尿病。与非糖尿病男性相比，他们年龄更大（p=0.017），99 名男性的 BCF 更低（p<0.001）。铁过载指标均与糖尿病无关。
结论
我们的研究结果对铁过载在 2 型糖尿病发病机制中的作用提出了质疑。
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