Department of Biological Science and Technology, National Chiao Tung University, Taichung, Taiwan.
Taiwan J Obstet Gynecol. 2010 Sep;49(3):247-53. doi: 10.1016/S1028-4559(10)60056-3.
Leiomyomas (myoma or fibroid) are the most common gynecologic tumors that occur in women of reproductive age, but their molecular pathogenesis is still unknown. Since the growth of leiomyomas involve numerous vascular factors, an association between the leiomyoma and growth factors is suspected. Vascular endothelial growth factor (VEGF) is one of the most important angiogenic growth factors. VEGF regulates angiogenesis and mediates sex steroid-induced cell growth and differentiation. VEGF-mediated activities seem to contribute to the pathogenesis of leiomyoma. Genetic variations, including polymorphisms, in VEGF might also be associated with the complex pathogenesis of leiomyomas. Here, we performed a systematic review of the roles of VEGF and its polymorphisms in the pathogenesis of leiomyoma.
平滑肌瘤（肌瘤或纤维瘤）是最常见的妇科肿瘤，发生在育龄妇女中，但它们的分子发病机制尚不清楚。由于平滑肌瘤的生长涉及许多血管因素，因此怀疑平滑肌瘤与生长因子之间存在关联。血管内皮生长因子（VEGF）是最重要的血管生成生长因子之一。VEGF 调节血管生成，并介导性激素诱导的细胞生长和分化。VEGF 介导的活性似乎有助于平滑肌瘤的发病机制。VEGF 中的遗传变异，包括多态性，也可能与平滑肌瘤的复杂发病机制有关。在这里，我们对 VEGF 及其多态性在平滑肌瘤发病机制中的作用进行了系统评价。
