Roman H, Bourdel N, Canis M, Rigaud J, Delavierre D, Labat J-J, Sibert L
Clinique gynécologique et obstétricale, CHU de Rouen, 76000 Rouen, France.
Prog Urol. 2010 Nov;20(12):1003-9. doi: 10.1016/j.purol.2010.08.003. Epub 2010 Sep 29.
To analyse pathophysiology of adhesions and their link with chronic pelvic pain, as well as therapeutic and prevention options as reported in the literature.
Review of articles and consensus conferences published on this topic in the Medline (Pubmed) database, selected according to their scientific relevance.
Postoperative adhesions are responsible for a specific morbidity combining chronic pain, small bowel obstruction, infertility, and morbidity increase in the event of subsequent surgery. Chronic pains in previously operated on patients can be linked to postoperative adhesions. Ultrasonography and dynamic MRI can recognize intra abdominal adhesions, but cannot definitely link them to the painful symptoms. The prevention of adhesions is done firstly by respecting surgical rules concerning laparoscopic and open surgical approaches, and secondly by the use of anti-adhesion products. Pharmacological adhesion prevention systems decrease the frequency and extent of adhesions. Their efficiency has been proved by studies with substantial evidence levels. Patients suffering from potentially adhesion-induced chronic abdominal and pelvic pains can benefit from a laparoscopic adhesiolysis, which improved pain symptoms in more than 50% of patients, but exposes to the risk of complications, such as bowel injury.
The decision to perform adhesiolysis should be taken for each patient individually, while taking in consideration the benefit-to-risk ratio. Adhesion relapse after adhesiolysis is a frequent phenomenon, but can be reduced by the use of anti-adhesion products.
分析粘连的病理生理学及其与慢性盆腔痛的联系,以及文献报道的治疗和预防方法。
回顾Medline(Pubmed)数据库中发表的关于该主题的文章和共识会议,根据其科学相关性进行筛选。
术后粘连会导致特定的发病率,包括慢性疼痛、小肠梗阻、不孕,以及后续手术时发病率增加。既往接受过手术的患者出现的慢性疼痛可能与术后粘连有关。超声检查和动态磁共振成像可识别腹腔内粘连,但无法明确将其与疼痛症状联系起来。粘连的预防首先要遵守腹腔镜和开放手术入路的手术规则,其次是使用抗粘连产品。药物性粘连预防系统可降低粘连的频率和程度。大量证据水平的研究已证实其有效性。患有可能由粘连引起的慢性腹部和盆腔疼痛的患者可受益于腹腔镜粘连松解术,该手术可使超过50%的患者疼痛症状得到改善,但存在肠损伤等并发症风险。
粘连松解术的决策应针对每个患者单独做出,同时考虑利弊比。粘连松解术后粘连复发是常见现象,但使用抗粘连产品可降低复发率。