重组人血小板衍生生长因子-BB（rhPDGF-BB）在肌肉骨骼修复中的演变及其在足踝融合手术中的作用。

The evolution of rhPDGF-BB in musculoskeletal repair and its role in foot and ankle fusion surgery.

作者信息

DiGiovanni Christopher W, Petricek James M

机构信息

Division of Foot and Ankle Surgery, Department of Orthopaedic Surgery, The Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02904, USA.

出版信息

Foot Ankle Clin. 2010 Dec;15(4):621-40. doi: 10.1016/j.fcl.2010.07.001.

DOI:10.1016/j.fcl.2010.07.001

PMID:21056861

Abstract

Platelet-derived growth factor (PDGF) is one of the most thoroughly studied proteins in the body. Research has progressively highlighted the role of PDGF during wound healing and in the bone repair cascade. This research has resulted in FDA approval of 2 products containing a recombinant version of the protein, rhPDGF-BB, for treating chronic diabetic foot ulcers and periodontal bone defects. This article reviews the applicable basic science and mechanisms of action of PDGF, with attention to the increasingly defined role of rhPDGF-BB in initiating bone regeneration. The most recent data from prospective clinical trials evaluating the use of rhPDGF-BB in combination with beta tricalcium phosphate as a substitute for autogenous bone graft in hindfoot and ankle arthrodesis are also summarized.

摘要

血小板衍生生长因子（PDGF）是体内研究最为深入的蛋白质之一。研究已逐步凸显了PDGF在伤口愈合及骨修复级联反应中的作用。这项研究促使美国食品药品监督管理局（FDA）批准了2种含有该蛋白重组形式——重组人血小板衍生生长因子-BB（rhPDGF-BB）的产品，用于治疗慢性糖尿病足溃疡和牙周骨缺损。本文回顾了PDGF适用的基础科学及作用机制，重点关注rhPDGF-BB在启动骨再生中日益明确的作用。还总结了评估rhPDGF-BB与β-磷酸三钙联合用于后足和踝关节融合术替代自体骨移植的前瞻性临床试验的最新数据。