Department of Psychiatry, University of Patras School of Medicine, Rion Patras, Greece.
Ann Hepatol. 2010 Oct-Dec;9(4):419-27.
It is well established that chronic viral hepatitis (CVH) negatively affects patients . health-related quality of life (HRQOL). The aim of the present study was to assess the extent to which fatigue and depressive symptoms are associated with CVH patients. HRQOL.
Eighty-four adult CVH outpatients [45 with hepatitis B virus (HBV) and 39 with hepatitis C virus (HCV) infection] participated in the study. The Short Form-36 Health Survey (SF-36), the Beck Depression Inventory-II (BDI-II) and the Fatigue subscale of the Functional Assessment of Cancer Therapy-Anemia Scale (FACT-F) were used to assess HRQOL, depression and fatigue, respectively.
All aspects of HRQOL perceived by CVH patients were significantly impaired compared to the general population, as a comparison with Greek population-based normative data revealed. HBV patients presented similar HRQOL with HCV patients. Clinical parameters including infection activity, fibrosis stage or inflammation grade, as well as depressive symptoms and fatigue were found to be significantly associated with HRQOL. Multivariate analyses showed that older age (p <0.001) and higher fatigue scores (p <0.001) were the variables most closely associated with the physical HRQOL, whereas higher rates on depressive symptoms (p <0.0005) and fatigue (p <0.020) scales were the variables most closely associated with the mental HRQOL.
In conclusion, CVH is associated with impaired HRQOL. Fatigue and impaired psychological functioning is associated with diminished HRQOL in CHV, independent of the disease etiology. Consequently, management of fatigue and depressive symptoms should be considered a priority, in order to improve HRQOL in CVH patients.
慢性病毒性肝炎（CVH）对患者健康相关生活质量（HRQOL）有负面影响，这一点已得到充分证实。本研究的目的是评估疲劳和抑郁症状与 CVH 患者 HRQOL 的关联程度。
84 名成年 CVH 门诊患者（45 名乙型肝炎病毒[HBV]感染者和 39 名丙型肝炎病毒[HCV]感染者）参与了这项研究。使用简短形式-36 健康调查（SF-36）、贝克抑郁量表-II（BDI-II）和癌症治疗贫血量表功能评估-F 疲劳量表（FACT-F）分别评估 HRQOL、抑郁和疲劳。
与一般人群相比，CVH 患者感知的所有 HRQOL 方面都明显受损，因为与希腊基于人群的规范数据进行比较显示了这一点。HBV 患者的 HRQOL 与 HCV 患者相似。临床参数，包括感染活动、纤维化阶段或炎症等级，以及抑郁症状和疲劳，都与 HRQOL 显著相关。多变量分析显示，年龄较大（p <0.001）和疲劳评分较高（p <0.001）是与身体 HRQOL 最密切相关的变量，而抑郁症状（p <0.0005）和疲劳（p <0.020）评分较高是与心理 HRQOL 最密切相关的变量。
总之，CVH 与 HRQOL 受损有关。疲劳和心理功能障碍与 CHV 中 HRQOL 下降有关，与疾病病因无关。因此，应考虑优先管理疲劳和抑郁症状，以改善 CVH 患者的 HRQOL。
