Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006, P. R. China.
Analyst. 2011 Jan 21;136(2):299-303. doi: 10.1039/c0an00633e. Epub 2010 Nov 8.
Upon addition of a small amount of bromocyclohexane, propranolol displays room temperature phosphorescence in γ-cyclodextrin solution without deoxygenation. Several factors including the pH, and the concentration of γ-cyclodextrin and bromocyclohexane, which affect the room temperature phosphorescence (RTP) intensity and room temperature phosphorescence lifetime of propranolol are studied in detail. Under optimal conditions, the room temperature phosphorescence lifetimes of propranolol enantiomers are measured. The experimental results show that the associated phosphorescence decay curves can be best fitted to mono-exponential patterns and room temperature phosphorescence lifetimes of R- and S-propranolol are 4.60 ms and 5.74 ms, respectively. The difference of the room temperature phosphorescence lifetimes of R- and S-propranolol is 22.05%. Based on that, chiral discrimination of propranolol enantiomers is carried out successfully by time-resolved phosphorescence.
当加入少量溴代环己烷时，普萘洛尔在不加脱氧剂的γ-环糊精溶液中显示室温磷光。详细研究了影响普萘洛尔室温磷光（RTP）强度和寿命的几种因素，包括 pH 值以及γ-环糊精和溴代环己烷的浓度。在最佳条件下，测量了普萘洛尔对映体的室温磷光寿命。实验结果表明，关联的磷光衰减曲线可以最好地拟合单指数模式，R-和 S-普萘洛尔的室温磷光寿命分别为 4.60ms 和 5.74ms。R-和 S-普萘洛尔的室温磷光寿命差为 22.05%。基于此，通过时间分辨磷光成功地对普萘洛尔对映体进行了手性区分。
