Morita C, Ikuta K, Goto T, Sano K, Nakai M, Hirai K, Kato S
Department of Pathology, Osaka University, Japan.
J Acquir Immune Defic Syndr (1988). 1990;3(3):231-7.
Several cell clones producing teardrop-shaped human immunodeficiency virus type 1 (HIV-1) particles were isolated from MT-4 cells that survived HIV-1 infection after extensive cell lysis. Most of the teardrop-shaped particles contained an electron-dense core structure, and the particles could replicate in MT-4 cells. No significant structural difference in the HIV-1 proteins was observed between these cell clones and the MOLT-4 cells producing intact HIV-1 particles, although their envelope structure is morphologically abnormal.
从在广泛细胞裂解后仍存活于HIV-1感染中的MT-4细胞中分离出了几个产生泪滴状1型人类免疫缺陷病毒（HIV-1）颗粒的细胞克隆。大多数泪滴状颗粒含有电子致密的核心结构，并且这些颗粒能够在MT-4细胞中复制。尽管这些细胞克隆产生的HIV-1颗粒的包膜结构在形态上异常，但其HIV-1蛋白与产生完整HIV-1颗粒的MOLT-4细胞之间未观察到明显的结构差异。
