Hizuka N, Takano K, Shizume K, Kawai K
Acta Endocrinol (Copenh). 1978 Aug;88(4):625-32. doi: 10.1530/acta.0.0880625.
The levels of serum somatomedin A were determined in 59 growth retarded Japanese children by a radioreceptor assay. Low levels were found in 10 children with growth hormone (GH) deficiency and 7 children with relative GH deficiency with means of 0.26 +/- 0.48 +/- 0.04 U/ml, respectively. Serum somatomedin A levels in 42 retarded children with normal growth hormone levels were within the range of normal adults, and did not correlate with degree of short stature. Significant increases of somatomedin A after hGH administration were found in children with growth hormone deficiency but not in children with normal growth hormone. These results show that determination of somatomedin A in serum corelates well with the state of growth hormone secretion, and is of great importance in the selection of patients for treatment with human growth hormone.
采用放射受体分析法对59名生长迟缓的日本儿童测定了血清生长调节素A水平。在10名生长激素（GH）缺乏儿童和7名相对GH缺乏儿童中发现水平较低，其均值分别为0.26 +/- 0.48 +/- 0.04 U/ml。42名生长激素水平正常的生长迟缓儿童的血清生长调节素A水平在正常成人范围内，且与身材矮小程度无关。生长激素缺乏儿童在给予hGH后生长调节素A显著升高，而生长激素正常的儿童则未出现这种情况。这些结果表明，血清生长调节素A的测定与生长激素分泌状态密切相关，在选择生长激素治疗患者方面具有重要意义。
