设计用于抗原递送的聚合物颗粒。
Designing polymeric particles for antigen delivery.
机构信息
Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium.
出版信息
Chem Soc Rev. 2011 Jan;40(1):320-39. doi: 10.1039/b914943k. Epub 2010 Nov 9.
DOI:10.1039/b914943k
PMID:21060941
Abstract
By targeting dendritic cells, polymeric carriers in the nano to lower micron range constitute very interesting tools for antigen delivery. In this critical review, we review how new immunological insights can be exploited to design new carriers allowing one to tune immune responses and to further increase vaccine potency (137 references).
摘要
通过靶向树突状细胞，纳米到亚微米范围内的聚合物载体构成了用于抗原递呈的非常有趣的工具。在这篇评论中，我们回顾了如何利用新的免疫学见解来设计新的载体，从而可以调节免疫反应并进一步提高疫苗效力（引用了 137 篇参考文献）。
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