Ono H, Nagano N, Yamada M, Fukuda H
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Neuropharmacology. 1990 Jan;29(1):69-74. doi: 10.1016/0028-3908(90)90085-6.
Experiments were performed on spinalized rats, transected at the Cl level. The intravenous administration of TRH and its analog YM-14673 (N alpha-[(S)-4-oxo-2-azetidinyl) carbonyl]-L-histidyl-L-prolinamide dehydrate) produced marked increases in the amplitude of mono- and polysynaptic reflex potentials and those of the withdrawal flexor reflexes. The effects of YM-14673 were stronger and longer-lasting than those of TRH. The stimulant action of TRH and YM-14673 on the flexor reflexes was not antagonized by prazosin, chlorpromazine, haloperidol or cyproheptadine, suggesting no involvement of the release of catecholamines or serotonin in the stimulant effects of TRH and its analog. Therefore, YM-14673 may be beneficial for the treatment of several spinal motor neuron diseases.
实验在C1水平横断脊髓的大鼠身上进行。静脉注射促甲状腺激素释放激素（TRH）及其类似物YM - 14673（Nα-[(S)-4-氧代-2-氮杂环丁烷基)羰基]-L-组氨酰-L-脯氨酰胺脱水物）可使单突触和多突触反射电位以及屈肌反射电位的幅度显著增加。YM - 14673的作用比TRH更强且更持久。TRH和YM - 14673对屈肌反射的兴奋作用不受哌唑嗪、氯丙嗪、氟哌啶醇或赛庚啶的拮抗，这表明TRH及其类似物的兴奋作用不涉及儿茶酚胺或5-羟色胺的释放。因此，YM - 14673可能对几种脊髓运动神经元疾病的治疗有益。
