Department of Pharmacology, Chung-Ang University, Seoul, South Korea.
Am J Chin Med. 2010;38(6):1207-22. doi: 10.1142/S0192415X10008573.
Microbial products, including lipopolysaccharides, may be involved in the pathogenesis of inflammatory skin diseases. We examined the effect of hirsutenoxime on the Toll-like receptor 4-mediated activation of Akt and nuclear factor (NF)-κB in lipopolysaccharide-stimulated keratinocytes. Hirsutenoxime, a cell signaling Akt inhibitor, and Bay 11-7085, an inhibitor of NF-κB activation, attenuated the lipopolysaccharide-induced expression of Toll-like receptor 4, activation of NF-κB and Akt, and the production of chemokines and reactive oxygen/nitrogen species. Hirsutenoxime may reduce the Toll-like receptor 4 expression-mediated NF-κB activation, which is regulated by the Akt pathway in keratinocytes exposed to lipopolysaccharides. This effect may reduce the skin inflammatory response.
微生物产物，包括脂多糖，可能参与炎症性皮肤病的发病机制。我们研究了毛喉素肟对脂多糖刺激角质细胞中 Toll 样受体 4 介导的 Akt 和核因子 (NF)-κB 激活的影响。毛喉素肟是一种细胞信号 Akt 抑制剂，Bay 11-7085 是 NF-κB 激活的抑制剂，可减弱脂多糖诱导的 Toll 样受体 4 表达、NF-κB 和 Akt 的激活以及趋化因子和活性氧/氮物质的产生。毛喉素肟可能会降低角质细胞暴露于脂多糖时 Toll 样受体 4 表达介导的 NF-κB 激活，该激活受 Akt 通路调节。这种作用可能会减轻皮肤炎症反应。
