Koslovskiĭ A G, Zhelifonova V P, Antipova T V, Zelenkova N F
Prikl Biokhim Mikrobiol. 2010 Sep-Oct;46(5):572-6.
The fungus P. citrinum produces secondary metabolites, clavine ergot alkaloids (EA), and quinoline alkaloids quinocitrinines (QA) in medium with various carbon and nitrogen sources and in the presence of iron, copper, and zinc additives. Mannitol and sucrose are most favorable for EA biosynthesis and mannitol is most favorable for QA. Maximum alkaloid production is observed on urea. Iron and copper additives in the medium containing zinc ions stimulated fungal growth but inhibited alkaloid biosynthesis. The production of these secondary metabolites does not depend on the physiological state of culture, probably due to the constitutive nature of the enzymes involved in biosynthesis of these substances.
桔青霉在含有各种碳源和氮源的培养基中，以及在铁、铜和锌添加剂存在的情况下，会产生次级代谢产物——棒麦角生物碱（EA）和喹啉生物碱喹诺桔霉素（QA）。甘露醇和蔗糖最有利于EA的生物合成，而甘露醇最有利于QA的合成。在尿素上观察到生物碱产量最高。在含有锌离子的培养基中添加铁和铜会刺激真菌生长，但会抑制生物碱的生物合成。这些次级代谢产物的产生不依赖于培养物的生理状态，这可能是由于参与这些物质生物合成的酶具有组成型性质。
