Makunin I V, Iurlova A A
Genetika. 2010 Sep;46(9):1202-4.
Mobile genetic elements affect structure and function in various ways. Significant number of genes in human and mouse are transcribed from alternative promoters located in LTR retrotransposons. As a rule, these retrotransposons are located upstream of annotated genes, and their promoters initiate transcription of alternative first exon. We investigated role of LTR retrotransposons in expression of genes in Drosophila. Using database of spliced ESTs we identified only 13 potential cases of transcription initiation from long terminal repeats of LTR within euchromatic part of the Drosophila genome. Our results indicate on insignificant role of promoters of LTR retrotransposons in expression of genes in Drosophila.
移动遗传元件以多种方式影响结构和功能。人类和小鼠中有相当数量的基因是从位于LTR逆转录转座子中的可变启动子转录而来的。通常,这些逆转录转座子位于注释基因的上游,它们的启动子启动可变第一外显子的转录。我们研究了LTR逆转录转座子在果蝇基因表达中的作用。利用剪接EST数据库,我们仅在果蝇基因组常染色质部分的LTR长末端重复序列中鉴定出13个潜在的转录起始案例。我们的结果表明,LTR逆转录转座子的启动子在果蝇基因表达中作用不大。