Kuyumcuoglu U, Guzel A I, Celik Y, Erdemoğlu M
Department of Obstetrics and Gynecology, Dicle University, Faculty of Medicine, Diyarbakir, Turkey.
Eur J Gynaecol Oncol. 2010;31(5):514-6.
We assessed the association of preoperative thrombocytosis with prognostic factors in malign ovarian tumor.
Over a five-year period, cases treated for ovarian cancer were randomly assigned. The data were collected from gynecological oncology, radiation oncology, medical oncology and pathology departments. Statistical analyses were carried out by using the statistical packages for SPSS 12.0 for Windows (Chicago, IL, USA). Survival was analyzed by the method of Kaplan and Meier, using log-rank (Mantel-Cox) analysis.
51 cases with ovarian cancer were evaluated. Cases with thrombocytosis were found to have greater CA-125 levels, more advanced stage disease, more ascites and shorter periods of survival.
Thrombocytosis is a poor prognostic factor in ovarian cancer. As reported previously, it is associated with aggressive tumor biology. Thus, preoperative thrombocytosis can be a used as a marker of poor outcomes.
