Peña J M, Arnalich F, Barbado F J, Dominguez A, Mostaza J, Valencia M E, Vazquez J J
Department of Internal Medicine, Faculty of Medicine, Hospital La Paz, Madrid, Spain.
Acta Haematol. 1990;83(2):86-8. doi: 10.1159/000205174.
Five patients, two homosexuals and three drug abusers, with HIV-related severe thrombocytopenia, four of whom had also bleeding episodes, experienced a full remission of thrombocytopenia after 1,200 mg/day zidovudine treatment. None of the patients had acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. Platelet counts began an upward trend at the end of the 3rd week and reached values higher than 140 x 10(9)/l towards the end of the 8th week of treatment. Patient's platelets remained stable after more than 4 months of active treatment. This is the first report of zidovudine-induced long-term remission of HIV-associated severe thrombocytopenia.
五名患者，其中两名同性恋者和三名药物滥用者，患有与HIV相关的严重血小板减少症，其中四人还出现过出血发作，在接受每日1200毫克齐多夫定治疗后血小板减少症完全缓解。这些患者均未患有获得性免疫缺陷综合征（AIDS）或AIDS相关综合征。血小板计数在第3周结束时开始呈上升趋势，在治疗第8周结束时达到高于140×10⁹/L的值。经过4个多月的积极治疗后，患者的血小板保持稳定。这是齐多夫定诱导HIV相关严重血小板减少症长期缓解的首例报告。
