Abbott Bioresearch Center, Worcester, Massachusetts, USA.
Ann N Y Acad Sci. 2010 Nov;1211:95-106. doi: 10.1111/j.1749-6632.2010.05813.x.
Age-related bone loss is a common worldwide phenomenon in the aging population, placing them at an increased risk of fractures. Fortunately, basic and translational studies have been pivotal in providing us with a mechanistic understanding of the cellular and molecular pathophysiology of this condition. This review focuses on the current concepts and paradigms of age-related bone loss and how various animal and cellular models have broadened our understanding in this fascinating but complex area. Changes in hormonal, neuronal, and biochemical cues with age and their effect on bone have been discussed. This review also outlines recent studies on the relationship between bone and fat in the marrow, as well as the fate of the marrow mesenchymal stromal cell population, which can give rise to either bone-forming osteoblasts or fat-forming adipocytic cells as a function of age.
与年龄相关的骨丢失是老龄化人口中一种常见的全球现象，使他们面临骨折风险增加。幸运的是，基础和转化研究对于提供我们对这种疾病的细胞和分子病理生理学的机制理解至关重要。本综述重点介绍了与年龄相关的骨丢失的当前概念和范例，以及各种动物和细胞模型如何拓宽我们在这个迷人但复杂领域的理解。讨论了年龄相关的激素、神经元和生化线索的变化及其对骨骼的影响。本综述还概述了最近关于骨髓中骨与脂肪之间关系的研究，以及骨髓间充质基质细胞群体的命运，该群体可以根据年龄分化为形成骨的成骨细胞或形成脂肪的脂肪细胞。
