Sry：哺乳动物性别决定的主控开关。

Sry: the master switch in mammalian sex determination.

机构信息

Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

出版信息

Development. 2010 Dec;137(23):3921-30. doi: 10.1242/dev.048983.

DOI:10.1242/dev.048983

PMID:21062860

Abstract

SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development.

摘要

SRY，哺乳动物的 Y 染色体睾丸决定基因，诱导雄性性别决定。最近在小鼠中的研究表明，SRY 的主要作用是实现相关基因 Sox9 的充分表达，以诱导支持细胞分化，进而驱动睾丸形成。在这里，我们讨论了由 SRY 触发的级联事件以及加强雄性睾丸分化并积极抑制卵巢发育的机制。