Alp Sehnaz
Hacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Enfeksiyon Hastalıkları Ünitesi, Ankara, Türkiye.
Mikrobiyol Bul. 2010 Jul;44(3):519-26.
Melanins can be produced by some species of pathogenic bacteria, helminths and fungi. The production of melanin appears to contribute to microbial pathogenesis owing to its potential for protection against host defence systems. Melanin synthesis in Cryptococcus neoformans has been associated with virulence by the ability to protect against phagocytosis, oxidative injury and phagocytic killing. Moreover, it was shown that, melanization of C.neoformans has involved in protection against some antifungal compounds. The detection of the association between melanin and microbial virulence might provide new treatment and prevention strategies targeting the inhibition of melanin polymerization. In this review article, the impact of melanin on virulence of C.neoformans has been discussed.
某些致病细菌、蠕虫和真菌能够产生黑色素。黑色素的产生似乎有助于微生物致病，因为它具有抵御宿主防御系统的潜力。新型隐球菌中的黑色素合成与毒力相关，因为它能够抵御吞噬作用、氧化损伤和吞噬杀伤。此外，研究表明，新型隐球菌的黑色素化参与了对某些抗真菌化合物的抵御。检测黑色素与微生物毒力之间的关联可能会提供针对抑制黑色素聚合的新治疗和预防策略。在这篇综述文章中，讨论了黑色素对新型隐球菌毒力的影响。
