School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, United Kingdom.
Int J Cancer. 2011 Sep 1;129(5):1199-206. doi: 10.1002/ijc.25739. Epub 2011 Feb 11.
Obese men appear to have an increased risk of being diagnosed with advanced prostate cancer and of dying from the disease. Few studies have examined the impact of weight gain during adulthood on prostate cancer risk and mortality and these have reported conflicting results. We analysed data from 20,991 Norwegian men who participated in two phases of the Nord-Trøndelag Health Study in 1984/1986 (HUNT-1, when aged at least 20 years) and 1995/1997 (HUNT-2). Weight and height were measured at both HUNT-1 and HUNT-2, allowing each man's change in weight and body mass index (BMI) to be computed. During a median of 9.3 years of follow-up after the end of HUNT-2, 649 (3%) men developed prostate cancer. We observed no increase in prostate cancer incidence amongst men who put on weight between HUNT-1 and HUNT-2. In multivariable models, including adjustment for weight at HUNT-2, the hazard ratio (HR) for prostate cancer per one standard deviation, SD (6.2 kg) gain in weight was 0.98 (95% confidence interval [95% CI]=0.87-1.10, p-trend=0.70) and per one SD gain in BMI (1.9 kg/m(2) ) was 0.99 (95% CI=0.90-1.10, p-trend=0.88). Amongst men diagnosed with prostate cancer (any stage), there was no evidence that gain in weight before diagnosis was positively associated with subsequent all-cause mortality (HR per one SD increase in weight=0.98; 95% CI=0.81-1.19, p-trend=0.86). We conclude that weight gain in adulthood had no effect on prostate cancer incidence or survival in this population.
肥胖男性似乎有更高的风险被诊断出晚期前列腺癌，并死于该疾病。很少有研究检查成年期体重增加对前列腺癌风险和死亡率的影响，而且这些研究报告的结果相互矛盾。我们分析了 20991 名挪威男性的数据，他们参加了 1984/1986 年（HUNT-1，年龄至少 20 岁）和 1995/1997 年（HUNT-2）两次挪威特隆赫姆健康研究的两个阶段。在 HUNT-1 和 HUNT-2 时都测量了体重和身高，从而可以计算出每个男性体重和体重指数（BMI）的变化。在 HUNT-2 结束后的中位 9.3 年随访期间，有 649（3%）名男性被诊断出患有前列腺癌。我们没有发现体重增加的男性前列腺癌发病率增加。在多变量模型中，包括对 HUNT-2 时体重的调整，体重每增加一个标准差（SD）（6.2 公斤），前列腺癌的风险比（HR）为 0.98（95%置信区间[95%CI]为 0.87-1.10，p 趋势=0.70），体重指数（BMI）每增加一个 SD（1.9 公斤/平方米）的 HR 为 0.99（95%CI=0.90-1.10，p 趋势=0.88）。在被诊断患有前列腺癌（任何阶段）的男性中，没有证据表明诊断前的体重增加与随后的全因死亡率呈正相关（体重每增加一个 SD 的 HR=0.98；95%CI=0.81-1.19，p 趋势=0.86）。我们的结论是，在该人群中，成年期体重增加对前列腺癌的发病率或生存没有影响。
