Karande V C, Jones G S, Veeck L L, Muasher S J
Howard and Georgeanna Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507.
Fertil Steril. 1990 Mar;53(3):486-9. doi: 10.1016/s0015-0282(16)53345-7.
In an attempt to improve their outcome with in vitro fertilization (IVF), 34 low-responder patients were stimulated with six ampules of follicle-stimulating hormone (FSH) daily starting on day 1 (n = 17) or day 2 (n = 17) of their menstrual cycles. The stimulated cycles showed a mean peak estradiol of 443 +/- 173 pg/mL, mean days of human chorionic gonadotropin of 7.6 +/- 1.4, 2.67 +/- 1.5 preovulatory oocytes per retrieval, and 2.56 +/- 1.3 oocytes per transfer. Three clinical pregnancies resulted after 25 embryo transfer cycles (12%). With paired analysis, we compared 8 patient cycles with prior six ampules of FSH stimulation starting on day 3; all parameters examined showed no significant differences. In a comparison of 22 patient cycles with prior 4 ampules of FSH stimulation on cycle day 3, no significant differences in any parameters were observed except in the higher number of ampules used in the present study. We conclude that high-dose FSH stimulation at the onset of the menstrual cycle does not improve the IVF outcome in low-responder patients.
为了通过体外受精（IVF）改善结局，34例低反应患者在月经周期第1天（n = 17）或第2天（n = 17）开始每天用6支促卵泡激素（FSH）进行刺激。刺激周期的平均雌二醇峰值为443±173 pg/mL，人绒毛膜促性腺激素的平均天数为7.6±1.4天，每次取卵的排卵前卵母细胞平均为2.67±1.5个，每次移植的卵母细胞平均为2.56±1.3个。25个胚胎移植周期后有3例临床妊娠（12%）。通过配对分析，我们比较了8个患者周期，这些周期之前在第3天开始用6支FSH刺激；所有检查参数均无显著差异。在将22个患者周期与之前在周期第3天用4支FSH刺激的情况进行比较时，除了本研究中使用的FSH支数较多外，未观察到任何参数有显著差异。我们得出结论，月经周期开始时高剂量FSH刺激并不能改善低反应患者的IVF结局。
