Canale D, Mais V, Turchi P, Andreini F, Melis G B, Menchini-Fabris G F
Postgraduate School of Andrology, University of Pisa Medical School, Italy.
Fertil Steril. 1990 Mar;53(3):537-40. doi: 10.1016/s0015-0282(16)53353-6.
The effects of the administration of gonadotropin-releasing hormone (GnRH) on the increase of testis and prostate volume was monitored by ultrasound in six patients affected by idiopathic hypogonadotropic hypogonadism. A significant increase of testis volume was observed after 90 and 180 days (6.65 versus 3.32 mL, 99.1% net increase and 8.47 mL, 176.8% increase, respectively) of pulsatile GnRH treatment. A similar increase of prostate volume was observed at day 90 (12.67 versus 7.78 mL, 70.3% net increase) and day 180 (14.70 mL, 97.7% increase). The ultrasound monitoring of the modifications of testis and prostate volume may represent a biological assay of the effects of GnRH treatment and offer additional data on the response of target organs to the hormonal treatment.
通过超声监测了六名特发性低促性腺激素性性腺功能减退患者中促性腺激素释放激素（GnRH）给药对睾丸和前列腺体积增加的影响。在进行脉冲式GnRH治疗90天和180天后，观察到睾丸体积显著增加（分别为6.65 mL对3.32 mL，净增加99.1%；以及8.47 mL，增加176.8%）。在第90天（12.67 mL对7.78 mL，净增加70.3%）和第180天（14.70 mL，增加97.7%）观察到前列腺体积有类似增加。对睾丸和前列腺体积变化的超声监测可能代表了GnRH治疗效果的生物学测定，并提供了关于靶器官对激素治疗反应的额外数据。
