重组人α和γ干扰素治疗慢性乙型肝炎

Therapy of chronic hepatitis B with recombinant human alpha and gamma interferon.

作者信息

Di Bisceglie A M, Rustgi V K, Kassianides C, Lisker-Melman M, Park Y, Waggoner J G, Hoofnagle J H

机构信息

Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.

出版信息

Hepatology. 1990 Feb;11(2):266-70. doi: 10.1002/hep.1840110217.

DOI:10.1002/hep.1840110217

PMID:2106474

Abstract

Eight patients with chronic hepatitis B entered a pilot study of gamma interferon and alpha interferon in combination. Gamma interferon alone had minimal inhibitory effects on serum levels of hepatitis B virus as monitored by serum HBV DNA and DNA-polymerase activity. The drug also gave troublesome side effects. In contrast, alpha interferon had more potent inhibitory effects on serum HBV levels and fewer side effects. When combined, the two interferons showed no additive or synergistic effects in inhibiting serum levels of HBV DNA or DNA polymerase. These findings indicate that the addition of gamma interferon to alpha interferon provides no additional antiviral effects but contributes significantly to side effects.

摘要

八名慢性乙型肝炎患者进入了γ干扰素与α干扰素联合使用的初步研究。单独使用γ干扰素时，通过血清乙肝病毒DNA（HBV DNA）和DNA聚合酶活性监测发现，其对乙肝病毒血清水平的抑制作用微乎其微。该药物还会产生令人困扰的副作用。相比之下，α干扰素对血清乙肝病毒水平的抑制作用更强，副作用更少。联合使用时，两种干扰素在抑制血清HBV DNA或DNA聚合酶水平方面未显示出相加或协同作用。这些发现表明，在α干扰素基础上加用γ干扰素不会带来额外的抗病毒效果，反而会显著增加副作用。