Hillaire Marine Laure Bettina, Lawrence Philip, Lagrange Brice
Confluence: Sciences et Humanités (EA 1598), Université Catholique de Lyon, Lyon, France.
Immune Netw. 2023 Jun 15;23(4):e30. doi: 10.4110/in.2023.23.e30. eCollection 2023 Aug.
About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes.
每年约有80万人死于乙型肝炎病毒（HBV）感染。在约5%的成年感染者中，免疫系统无法有效对抗HBV感染，从而导致慢性乙型肝炎（CHB）。CHB与肝细胞癌相关，可导致患者死亡。不幸的是，尽管目前针对CHB的治疗能够控制HBV感染，但无法实现病毒的完全清除。IFN家族的细胞因子是固有免疫系统的一部分，是病毒清除的关键参与者。IFN分泌诱导干扰素刺激基因的表达，产生具有抗病毒特性且对细胞自主免疫至关重要的蛋白质。IFN-α通常用作CHB的治疗方法。此外，IFN-γ已被确定为急性感染期间负责清除HBV的主要IFN家族成员。在本综述中，我们总结了从HBV复制或感染的细胞或动物模型中获得的关于IFN-γ潜在抗HBV作用的关键证据，特别关注一些IFN-γ诱导基因。
