Asher L V, Walz M A, Notkins A L
Am J Obstet Gynecol. 1978 Aug 1;131(7):788-91. doi: 10.1016/0002-9378(78)90248-x.
Immunization of BALB/c mice with virulent and avirulent strains of HSV-1 resulted in high levels of neutralizing antibody and protected against both the lethal effect of the virus and the development of a latent ganglionic infection when animals were challenged by the intravaginal route. In animals immunized with avirulent strain of HSV-2 and challenged with a high virulent strain of HSV-2, substantial protection against death was observed despite low levels of neutralizing antibody. Nineteen per cent of the survivors, however, developed a latent ganglionic infection. Relatively little protection was observed in mice immunized with HSV-1 and challenged with HSV-2.
用1型单纯疱疹病毒（HSV-1）的强毒株和无毒株对BALB/c小鼠进行免疫接种，可产生高水平的中和抗体，并在动物经阴道途径受到攻击时，预防病毒的致死效应和潜伏性神经节感染的发生。在用2型单纯疱疹病毒（HSV-2）无毒株免疫并受到高毒株HSV-2攻击的动物中，尽管中和抗体水平较低，但仍观察到对死亡的显著保护作用。然而，19%的存活者发生了潜伏性神经节感染。在用HSV-1免疫并受到HSV-2攻击的小鼠中，观察到的保护作用相对较小。
