Lekstrom-Himes J A, Pesnicak L, Straus S E
Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA.
J Virol. 1998 Apr;72(4):2760-4. doi: 10.1128/JVI.72.4.2760-2764.1998.
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) have evolved specific anatomic tropisms and site-dependent rates of reactivation. To determine whether reactivation rates depend on distinct abilities of HSV-1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains of each virus were studied in the guinea pig genital model. Following infection with equivalent titers of virus, the quantities of latent HSV-2 genomes and LATs were higher in lumbosacral ganglia, and HSV-2 infections recurred more frequently and lasted longer than HSV-1 infections. In contrast, if the inoculum of HSV-1 was 10 times that of HSV-2, the quantity of HSV-1 DNA and LATs increased correspondingly and HSV-1 infections were as likely to recur as those with HSV-2. The quantity of latent virus DNA correlates with and may be a major determinant of the site-specific patterns and rates of reactivation of HSV-1 and -2.
1型和2型单纯疱疹病毒（HSV-1和HSV-2）已进化出特定的解剖嗜性和部位依赖性再激活率。为了确定再激活率是否取决于HSV-1和HSV-2建立潜伏状态和表达潜伏相关转录本（LATs）的不同能力，在豚鼠生殖器模型中研究了每种病毒的强毒株。用等量病毒滴度感染后，腰荐神经节中潜伏的HSV-2基因组和LATs的数量更高，并且HSV-2感染比HSV-1感染更频繁地复发且持续时间更长。相反，如果HSV-1的接种量是HSV-2的10倍，HSV-1 DNA和LATs的数量相应增加，并且HSV-1感染与HSV-2感染一样有可能复发。潜伏病毒DNA的数量与HSV-1和HSV-2的部位特异性模式及再激活率相关，并且可能是其主要决定因素。
