Khan Amir, Akhter Khalid
Department of Medicine, Bacha Khan, Medical College, Mardan, Pakistan.
J Ayub Med Coll Abbottabad. 2009 Oct-Dec;21(4):28-30.
Gonorrhoea is a purulent inflammation of mucus membrane of the genital tract and is a highly contagious sexually transmitted disease (STD) caused by the bacterium Neisseria gonorrhoae. Both men and women can be infected through a variety of sexual contact behaviours including vaginal, anal or oral intercourses. This comparative study was carried out in New Gulail Polyclinic Jeddah, KSA from Jan 2003 to March 2004 to find the clinical efficacy of ciprofloxacin, ceftriaxone and spectinomycin, the three commonly used drugs, in the treatment of gonorrhoea.
A total number of 300 patients suffering from gonorrhoea were included in this study. They were randomly divided into 3 groups of 100 patients each. Group-A patients were given Tablet Ciprofloxacin 500 mg, Group-B patients Injection Ceftriaxone 500 mg, and Group-C patients were put on Injection Spectinomycin 2 gm, all in stat dosage. On the 5th day following the treatment, all patients were re-examined and their clinical and laboratory findings were recorded and analysed.
On the 5th day following treatment the Group-A (n = 100) showed 9 (9%) partial response and 11 (11%) cases showed no response to Ciprofloxacin. In the Group-B (n = 100), 4 (4%) patients showed partial response and 6 (6%) patients showed no response to Ceftriaxone. In Group-C, out of 100 patients, 4 (4%) cases reported with partial response and 2 (2%) patients showed no response to Spectinomycin. The efficacy of these anti-microbial agents was the same in both the genders.
Anti-microbial susceptibility of N. gonorrhoeae to various antibiotics is gradually decreasing. In order to ensure full cure, all gonorrhoea patients should be followed-up after a single dosage of any antibiotic. Further research should continue for newer, effective, and preferably oral medication for the treatment of gonorrhoea.
淋病是生殖道黏膜的化脓性炎症，是由淋病奈瑟菌引起的一种高度传染性的性传播疾病（STD）。男性和女性均可通过包括阴道性交、肛交或口交在内的多种性接触行为感染。本比较研究于2003年1月至2004年3月在沙特阿拉伯王国吉达的新古拉伊综合诊所进行，旨在探究环丙沙星、头孢曲松和大观霉素这三种常用药物治疗淋病的临床疗效。
本研究共纳入300例淋病患者。他们被随机分为3组，每组100例。A组患者服用500毫克环丙沙星片，B组患者注射500毫克头孢曲松，C组患者注射2克大观霉素，均为单次剂量。治疗后第5天，对所有患者进行复查，并记录和分析他们的临床及实验室检查结果。
治疗后第5天，A组（n = 100）有9例（9%）部分缓解，11例（11%）对环丙沙星无反应。B组（n = 100）中，4例（4%）患者部分缓解，6例（6%）患者对头孢曲松无反应。C组100例患者中，4例（4%）部分缓解，2例（2%）患者对大观霉素无反应。这些抗菌药物对两性的疗效相同。
淋病奈瑟菌对各种抗生素的药敏性正在逐渐降低。为确保完全治愈，所有淋病患者在单次使用任何一种抗生素后均应进行随访。应继续开展进一步研究，寻找治疗淋病的更新、有效且最好是口服的药物。
