Henriksson P, Rasmanis G, Edhag O, Vesterqvist O, Gréen K
Department of Medicine, Huddinge Hospital, Stockholm, Sweden.
Prostaglandins. 1990 Jan;39(1):99-107. doi: 10.1016/0090-6980(90)90098-g.
The effects of the thromboxane synthase inhibitor CGS13080 on the in vivo synthesis of thromboxane and prostacyclin were determined in six healthy volunteers. Two different doses (0.08 and 0.25 mg/kg x h) were infused for six hours under strictly controlled conditions and 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha were measured in urine using gaschromatography--mass spectrometry. The in vivo synthesis of thromboxane was inhibited by 80-75% while there was no effect on the in vivo prostacyclin synthesis.
在六名健康志愿者身上测定了血栓素合酶抑制剂CGS13080对血栓素和前列环素体内合成的影响。在严格控制的条件下，以两种不同剂量（0.08和0.25mg/kg·h）输注6小时，并用气相色谱-质谱法测定尿液中的2,3-二去甲血栓素B2（2,3-dinor-TxB2）和2,3-二去甲-6-酮-前列环素F1α（2,3-dinor-6-keto-PGF1α）。血栓素的体内合成受到80%-75%的抑制，而对前列环素的体内合成没有影响。
