Kusunoki M, Shoji Y, Ikeuchi H, Yamagata K, Yamamura T, Utsunomiya J
Second Department of Surgery, Hyogo College of Medicine, Japan.
Surgery. 1990 Mar;107(3):311-5.
We report on the excitatory effect of gamma-aminobutyric acid, which increased after the oral administration of valproate sodium, on anal canal resting pressure in human beings, gamma-aminobutyric acid receptors. We used this drug in order to improve continence after ileoanal anastomosis. Seventeen patients (eight with ulcerative colitis and nine with adenomatosis coli) were tested after receiving ileoanal anastomosis. The placebo showed no effect, but valproate sodium could ameliorate frequent defecation and soiling and the resulting perianal skin complications. Increasing anal resting pressure was also observed during valproate sodium administration without the amplitude, frequency of peristaltic wave, or voluntary squeeze pressure being affected. These results suggest that the subchronic administration of valproate sodium may be useful in the treatment of minor incontinence after ileoanal anastomosis.
我们报告了γ-氨基丁酸（GABA）的兴奋作用，口服丙戊酸钠后其作用增强，该作用作用于人体肛管静息压力及GABA受体。我们使用这种药物以改善回肠肛管吻合术后的控便能力。17例患者（8例溃疡性结肠炎患者和9例结肠腺瘤病患者）在接受回肠肛管吻合术后接受了测试。安慰剂无效果，但丙戊酸钠可改善频繁排便和便污以及由此导致的肛周皮肤并发症。在给予丙戊酸钠期间还观察到肛管静息压力增加，而蠕动波的幅度、频率或随意挤压压力未受影响。这些结果表明，亚慢性给予丙戊酸钠可能对治疗回肠肛管吻合术后的轻度失禁有用。
