Department of Medicine 'T', Ichilov Hospital, Tel-Aviv, Israel.
Climacteric. 2011 Apr;14(2):215-6. doi: 10.3109/13697137.2010.533615. Epub 2010 Nov 11.
The incidence of meningiomas is two to three times higher in women than in men, yet it is a rare event (around one case per 10 000 woman-years). Preclinical and clinical studies point at potential effects of female sex hormones on brain tumors. Results from several prospective, large-scale studies indicate that postmenopausal hormone therapy may increase the risk for diagnosing meningioma by 30-80%, but there is no effect in regard to glioma. However, because of the very low incidence of meningioma in the general population of women, the absolute excess risk attributed to hormone therapy has no clinical impact.
脑膜瘤的发病率女性比男性高 2 至 3 倍，但它是一种罕见的疾病（每 10000 名女性中约有一例）。临床前和临床研究表明女性性激素可能对脑肿瘤有潜在影响。几项前瞻性、大规模研究的结果表明，绝经后激素治疗可能会使脑膜瘤的诊断风险增加 30-80%，但对神经胶质瘤没有影响。然而，由于脑膜瘤在女性普通人群中的发病率非常低，因此激素治疗引起的绝对超额风险没有临床意义。
