白细胞介素-6：局部疼痛触发因素？
Interleukin-6: a local pain trigger?
出版信息
Arthritis Res Ther. 2010;12(5):145. doi: 10.1186/ar3138. Epub 2010 Oct 28.
Abstract
Pain management in conditions of chronic inflammation is a clinical challenge, and increasing our understanding of the mechanisms driving this type of pain is important. In the previous issue of Arthritis Research & Therapy, Boettger and colleagues examine the role of IL-6 in antigen-induced arthritis using the IL-6 neutralizing soluble glycoprotein 130 and link IL-6 to a pathophysiological role in the generation of pain, independent of the proinflammatory properties of IL-6. The findings presented in this study add to a growing body of evidence highlighting the role of IL-6 in the induction and maintenance of pain.
摘要
在慢性炎症情况下进行疼痛管理是一项临床挑战，加深我们对导致这种类型疼痛的机制的理解非常重要。在之前一期的《关节炎研究与治疗》中，Boettger 及其同事使用 IL-6 中和可溶性糖蛋白 130 研究了 IL-6 在抗原诱导关节炎中的作用，并将 IL-6 与疼痛产生的病理生理作用联系起来，而与 IL-6 的促炎特性无关。本研究提出的结果增加了越来越多的证据，突出了 IL-6 在诱导和维持疼痛中的作用。
相似文献
1
Interleukin-6: a local pain trigger?白细胞介素-6：局部疼痛触发因素？
Arthritis Res Ther. 2010;12(5):145. doi: 10.1186/ar3138. Epub 2010 Oct 28.
2
Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis.伤害性感觉神经元对白介素-6依赖的抗原诱导性关节炎的影响
Arthritis Res Ther. 2015 Nov 21;17:334. doi: 10.1186/s13075-015-0858-0.
3
Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis.局部和全身给予可溶性糖蛋白 130 对实验性关节炎疼痛和炎症的差异影响。
Arthritis Res Ther. 2010;12(4):R140. doi: 10.1186/ar3079. Epub 2010 Jul 13.
4
A directly GP130-targeting small molecule ameliorates collagen-induced arthritis (CIA) by inhibiting IL-6/GP130 signalling and Th17 differentiation.一种直接靶向 GP130 的小分子通过抑制 IL-6/GP130 信号和 Th17 分化来改善胶原诱导性关节炎 (CIA)。
Clin Exp Pharmacol Physiol. 2020 Apr;47(4):628-639. doi: 10.1111/1440-1681.13215. Epub 2020 Jan 24.
5
Key role of suppressor of cytokine signaling 3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory arthritis.细胞因子信号转导抑制因子 3 在调节 gp130 细胞因子诱导的信号转导和限制小鼠炎症性关节炎期间软骨细胞反应中的关键作用。
Arthritis Rheumatol. 2014 Sep;66(9):2391-402. doi: 10.1002/art.38701.
6
Spinal interleukin-6 is an amplifier of arthritic pain in the rat.脊髓白细胞介素-6是大鼠关节炎疼痛的放大器。
Arthritis Rheum. 2012 Jul;64(7):2233-42. doi: 10.1002/art.34384.
7
Targeting the glycoprotein 130 receptor subunit to control pain and inflammation.靶向糖蛋白 130 受体亚基以控制疼痛和炎症。
J Interferon Cytokine Res. 2010 Dec;30(12):865-73. doi: 10.1089/jir.2010.0035. Epub 2010 Oct 27.
8
Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.表没食子儿茶素-3-没食子酸酯通过增强可溶性gp130的产生来抑制IL-6合成并抑制转信号传导。
Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14692-7. doi: 10.1073/pnas.0802675105. Epub 2008 Sep 16.
9
Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.可溶性 gp130 可阻止白细胞介素-6 和白细胞介素-11 簇信号传递，但不能阻止细胞内自分泌反应。
Sci Signal. 2018 Oct 2;11(550):eaar7388. doi: 10.1126/scisignal.aar7388.
10
Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling.白细胞介素-6家族信号转导子gp130的不同可溶性形式微调白细胞介素-6反式信号传导的阻断作用。
J Biol Chem. 2016 Jul 29;291(31):16186-96. doi: 10.1074/jbc.M116.718551. Epub 2016 May 23.
引用本文的文献
1
Osteosarcopenia and Pain: Do We Have a Way Out?骨少肌症与疼痛：我们有解决办法吗？
Biomedicines. 2023 Apr 26;11(5):1285. doi: 10.3390/biomedicines11051285.
2
Blocking toll-like receptor 4 mitigates static loading induced pro-inflammatory expression in intervertebral disc motion segments.阻断 Toll 样受体 4 减轻静态负荷诱导的椎间盘运动节段促炎表达。
J Biomech. 2023 Mar;150:111491. doi: 10.1016/j.jbiomech.2023.111491. Epub 2023 Feb 11.
3
Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.白细胞介素-6 信号转导以性别特异性方式介导创伤后骨关节炎中的软骨降解和疼痛。
Sci Signal. 2022 Jul 26;15(744):eabn7082. doi: 10.1126/scisignal.abn7082.
4
Chronic Pain in Musculoskeletal Diseases: Do You Know Your Enemy?肌肉骨骼疾病中的慢性疼痛：你了解你的“敌人”吗？
J Clin Med. 2022 May 6;11(9):2609. doi: 10.3390/jcm11092609.
5
Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors.ω-3 脂肪酸和二十二碳六烯酸（DHA）水平升高与用 Janus 激酶抑制剂治疗的类风湿关节炎患者的疼痛减轻有关。
Nutrients. 2021 Aug 30;13(9):3050. doi: 10.3390/nu13093050.
6
Intercellular Arc Signaling Regulates Vasodilation.细胞间弧信号调节血管舒张。
J Neurosci. 2021 Sep 15;41(37):7712-7726. doi: 10.1523/JNEUROSCI.0440-21.2021. Epub 2021 Jul 29.
7
Neuroprotective and Anti-inflammatory Role of Atorvastatin and Its Interaction with Nitric Oxide (NO) in Chronic Constriction Injury-induced Neuropathic Pain.阿托伐他汀的神经保护和抗炎作用及其与一氧化氮（NO）在慢性缩窄性损伤诱导的神经性疼痛中的相互作用
Iran J Pharm Res. 2020 Fall;19(4):67-75. doi: 10.22037/ijpr.2020.1101230.
8
Pain: A Review of Interleukin-6 and Its Roles in the Pain of Rheumatoid Arthritis.疼痛：白细胞介素-6及其在类风湿关节炎疼痛中的作用综述
Open Access Rheumatol. 2021 Mar 5;13:31-43. doi: 10.2147/OARRR.S291388. eCollection 2021.
9
Effects of quercetin on exercise performance, physical activity and blood supply in a novel model of sustained hind-limb ischaemia.槲皮素对新型持续性后肢缺血模型中运动能力、身体活动及血液供应的影响
BJS Open. 2021 Jan 8;5(1). doi: 10.1093/bjsopen/zraa059.
10
The Price of Playing Through Pain: The Link Between Physical and Behavioral Health in Former NFL Athletes.《带伤比赛的代价：前 NFL 运动员身体和行为健康之间的关联》。
Am J Mens Health. 2020 Nov-Dec;14(6):1557988320975541. doi: 10.1177/1557988320975541.
本文引用的文献
1
Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis.局部和全身给予可溶性糖蛋白 130 对实验性关节炎疼痛和炎症的差异影响。
Arthritis Res Ther. 2010;12(4):R140. doi: 10.1186/ar3079. Epub 2010 Jul 13.
2
Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve injury through the activation of p38 MAPK.白细胞介素-6 通过激活 p38 MAPK 诱导外周神经损伤后脊髓小胶质细胞 CX3CR1 的表达。
Eur J Pain. 2010 Aug;14(7):682.e1-12. doi: 10.1016/j.ejpain.2009.10.017. Epub 2009 Dec 2.
3
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.外周感觉神经上表达的gp130在病理性疼痛中起关键作用。
J Neurosci. 2009 Oct 28;29(43):13473-83. doi: 10.1523/JNEUROSCI.1822-09.2009.
4
Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo.抑制白细胞介素-6受体可在体内外直接阻断破骨细胞的形成。
Arthritis Rheum. 2009 Sep;60(9):2747-56. doi: 10.1002/art.24781.
5
The role of IL-6 and IL-1beta in painful perineural inflammatory neuritis.白细胞介素-6和白细胞介素-1β在疼痛性神经周围炎性神经炎中的作用。
Brain Behav Immun. 2009 May;23(4):474-84. doi: 10.1016/j.bbi.2009.01.012. Epub 2009 Jan 29.
6
JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.外周神经损伤后，脊髓小胶质细胞中的JAK/STAT3信号通路被激活，并促进大鼠神经性疼痛的发展。
J Neurochem. 2008 Oct;107(1):50-60. doi: 10.1111/j.1471-4159.2008.05566.x. Epub 2008 Jul 12.
7
Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord.中枢敏化的细胞因子机制：白细胞介素-1β、白细胞介素-6和肿瘤坏死因子-α在调节脊髓浅层突触和神经元活动中的不同及重叠作用
J Neurosci. 2008 May 14;28(20):5189-94. doi: 10.1523/JNEUROSCI.3338-07.2008.
8
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial.托珠单抗抑制白细胞介素-6受体对类风湿关节炎患者的影响（OPTION研究）：一项双盲、安慰剂对照的随机试验。
Lancet. 2008 Mar 22;371(9617):987-97. doi: 10.1016/S0140-6736(08)60453-5.
9
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab.用于类风湿性关节炎的活性对照单药治疗研究，一种白细胞介素-6抑制剂（SAMURAI）：托珠单抗的X线阅片者盲法随机对照试验的临床和影像学获益证据
Ann Rheum Dis. 2007 Sep;66(9):1162-7. doi: 10.1136/ard.2006.068064. Epub 2007 May 7.
10
Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain.白细胞介素-6对大鼠关节神经无髓鞘感觉纤维机械刺激的致敏作用：关节疼痛的一种炎症机制。
Arthritis Rheum. 2007 Jan;56(1):351-9. doi: 10.1002/art.22282.
Zotero 插件