Kuroda Hajime, Nakai Maki, Ohnisi Kiyoshi, Ishida Takafumi, Kuroda Mina, Itoyama Shinji
Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Int J Surg Pathol. 2010 Oct;18(5):324-9. doi: 10.1177/1066896910375563.
The aim of this study was to determine lymph vessel invasion (LVI) and blood vessel invasion (BVI) using established biological markers and clinicopathological findings for triple-negative breast carcinoma. We reviewed all 202 cases of primary breast carcinoma that were surgically resected at Saitama Medical Center, Saitama Medical School, between 2006 and 2009. Tumor tissue was immunostained for estrogen receptor, progesterone receptor, Her2/neu, D2-40, and CD34. Among these, 26 cases of triple-negative carcinoma were reported retrospectively. The results were compared with those of 176 cases of non-triple-negative carcinomas that were included as controls. The frequency of LVI examined by hematoxylin and eosin and D2-40 (triple negative, 7 of 26; non-triple negative, 61 of 176) was not significantly different, and neither was BVI examined by HE, Elastica van Gieson, CD34 (triple negative, 2 of 26; non-triple negative, 16 of 176), and lymph node metastasis (triple negative 9 of 26, non-triple negative, 65 of 176). However, a specific pattern of distant metastasis with a high frequency of visceral metastases was detected in triple-negative carcinoma cases (triple negative, 6 of 26; non-triple negative, 8 of 176). Our findings show that triple-negative carcinoma of the breast may have a distinct biological behavior.
本研究旨在利用已确立的生物标志物和临床病理特征来确定三阴性乳腺癌的淋巴管浸润（LVI）和血管浸润（BVI）。我们回顾了2006年至2009年间在埼玉医科大学埼玉医疗中心手术切除的所有202例原发性乳腺癌病例。对肿瘤组织进行雌激素受体、孕激素受体、Her2/neu、D2-40和CD34免疫染色。其中，回顾性报告了26例三阴性癌病例。将结果与作为对照纳入的176例非三阴性癌病例的结果进行比较。苏木精和伊红染色以及D2-40检测的LVI频率（三阴性，26例中的7例；非三阴性，176例中的61例）无显著差异，HE染色、弹性纤维染色、CD34检测的BVI频率（三阴性，26例中的2例；非三阴性，176例中的16例）以及淋巴结转移率（三阴性，26例中的9例；非三阴性，176例中的65例）也无显著差异。然而，在三阴性癌病例中检测到一种远处转移的特定模式，内脏转移频率较高（三阴性，26例中的6例；非三阴性，176例中的8例）。我们的研究结果表明，乳腺三阴性癌可能具有独特的生物学行为。
