O-GlcNAc and aging: C. elegans as a genetic model to test O-GlcNAc roles in type II diabetic insulin resistance.
作者信息
Vosseller Keith
机构信息
Drexel University College of Medicine, Department of Biochemistry and Molecular Biology, Philadelphia, PA 19102, USA.
出版信息
Aging (Albany NY). 2010 Nov;2(11):749-51. doi: 10.18632/aging.100225.
Abstract
摘要
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O-GlcNAc and aging: C. elegans as a genetic model to test O-GlcNAc roles in type II diabetic insulin resistance.O-连接的N-乙酰葡糖胺与衰老：以秀丽隐杆线虫作为遗传模型来测试O-连接的N-乙酰葡糖胺在2型糖尿病胰岛素抵抗中的作用
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本文引用的文献
1
Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.细胞内蛋白质糖基化调节秀丽隐杆线虫中胰岛素介导的寿命。
Aging (Albany NY). 2010 Oct;2(10):678-90. doi: 10.18632/aging.100208.
2
Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity.动态 O-GlcNAc 循环在调控线虫寿命、应激和免疫的基因启动子上。
Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7413-8. doi: 10.1073/pnas.0911857107. Epub 2010 Apr 5.
3
Regulation of Dauer formation by O-GlcNAcylation in Caenorhabditis elegans.O-GlcNAcylation 调控秀丽隐杆线虫 dauer 形成。
J Biol Chem. 2010 Jan 29;285(5):2930-9. doi: 10.1074/jbc.M109.022665. Epub 2009 Nov 23.
4
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity.N-乙酰葡糖胺化与磷酸化之间的相互作用：在胰岛素抵抗和葡萄糖毒性中的作用
Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28. doi: 10.1152/ajpendo.90281.2008. Epub 2008 Apr 29.
5
Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats.O-连接的N-乙酰葡糖胺对蛋白质进行的翻译后修饰水平升高，会导致糖尿病Goto-Kakizaki大鼠胰腺中葡萄糖刺激的胰岛素分泌功能恶化。
Glycobiology. 2007 Feb;17(2):127-40. doi: 10.1093/glycob/cwl067. Epub 2006 Nov 9.
6
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.糖尿病易感性位点的秀丽隐杆线虫直系同源基因：oga-1（O-连接N-乙酰葡糖胺酶）敲除影响O-连接N-乙酰葡糖胺循环、代谢和滞育。
Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11952-7. doi: 10.1073/pnas.0601931103. Epub 2006 Aug 1.
7
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.秀丽隐杆线虫胰岛素抵抗模型：OGT-1基因敲除后大量营养素储存及滞育形成的改变
Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11266-71. doi: 10.1073/pnas.0408771102. Epub 2005 Jul 28.
8
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability.Ogt 依赖性 X 染色体连锁蛋白糖基化是体细胞功能和胚胎活力所必需的修饰。
Mol Cell Biol. 2004 Feb;24(4):1680-90. doi: 10.1128/MCB.24.4.1680-1690.2004.
9
O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar.O-连接的N-乙酰葡糖胺迎来二十岁：糖基化对核蛋白和胞质蛋白翻译后修饰的功能影响
FEBS Lett. 2003 Jul 3;546(1):154-8. doi: 10.1016/s0014-5793(03)00641-0.
10
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia.聚糖依赖性信号改变会诱发胰岛素抵抗和高瘦素血症。
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10695-9. doi: 10.1073/pnas.152346899. Epub 2002 Jul 22.
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