Martin-Luther-University Halle-Wittenberg, Institute for Physiological Chemistry, Halle, Germany.
Dev Dyn. 2010 Dec;239(12):3436-45. doi: 10.1002/dvdy.22487.
Vasculogenesis and hematopoiesis are closely linked in developing vertebrates. Recently, the existence of a common progenitor of these two tissues, the hemangioblast, has been demonstrated in different organisms. In Xenopus early vascular and hematopoietic cells differentiate in a region called the anterior ventral blood island (aVBI). Differentiating cells from this region migrate out to form embryonic blood and part of the vascular structures of the early frog embryo. A number of members of the ETS family of transcription factors are expressed in endothelial cells and some of them play important roles at various stages of vascular development. The loss of ER71 function in mice led to a complete loss of blood and vascular structures. Similarly, knock down of the zebrafish homolog of er71, etsrp, greatly affected development of vascular structures and myeloid cells. We have identified the Xenopus ortholog of er71 and could show that er71 function in Xenopus is required for vasculogenesis, but not for the development of hematopoietic cells.
在发育中的脊椎动物中，血管生成和造血密切相关。最近，在不同的生物体中已经证明了这两种组织的共同祖先是血岛细胞。在非洲爪蟾中，早期的血管和造血细胞在前腹血岛（aVBI）这个区域分化。来自这个区域的分化细胞迁移出去，形成胚胎血液和早期青蛙胚胎的一部分血管结构。ETS 家族的转录因子的许多成员在血管内皮细胞中表达，其中一些在血管发育的各个阶段发挥重要作用。在小鼠中，ER71 功能的丧失导致血液和血管结构的完全缺失。同样，斑马鱼 er71 同源物 etsrp 的敲除极大地影响了血管结构和髓样细胞的发育。我们已经鉴定出了非洲爪蟾 er71 的同源物，并能够证明非洲爪蟾 er71 的功能对于血管生成是必需的，但对于造血细胞的发育不是必需的。
