Suzuki S, Matsuda K, Isshiki N, Tamada Y, Yoshioka K, Ikada Y
Department of Plastic Surgery, Faculty of Medicine, Kyoto University, Japan.
Br J Plast Surg. 1990 Jan;43(1):47-54. doi: 10.1016/0007-1226(90)90044-z.
A bilayer "artificial skin" composed of an outer layer of silicone and an inner sponge layer of collagen and chondroitin sulphate has been developed by modifying the technique proposed by Yannas et al. (1980). Following experimental successes, the "artificial skin" was applied clinically. It was placed on the skin defects of 10 patients. Three weeks after application the outer layer of silicone sheet was peeled off and thin split thickness skin was grafted onto the newly synthesised dermis-like tissue. Secondary skin grafts took perfectly in all cases and postoperative appearance was satisfactory.
通过改进扬纳斯等人（1980年）提出的技术，研发出了一种双层“人造皮肤”，其外层为硅胶，内层是由胶原蛋白和硫酸软骨素构成的海绵层。经过实验成功后，这种“人造皮肤”被应用于临床。它被放置在10名患者的皮肤缺损处。应用三周后，将硅胶片外层剥离，然后将薄的断层皮片移植到新合成的类似真皮的组织上。在所有病例中，二期皮肤移植均完美成功，术后外观令人满意。
