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治疗腱病:自体全血和富含血小板的血浆注射有作用吗?

Treatment of tendinopathy: is there a role for autologous whole blood and platelet rich plasma injection?

机构信息

Department of Orthopaedics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

出版信息

Int J Clin Pract. 2010 Dec;64(13):1813-23. doi: 10.1111/j.1742-1241.2010.02432.x.

DOI:10.1111/j.1742-1241.2010.02432.x
PMID:21070532
Abstract

BACKGROUND

Chronic tendinopathies are a common source of disability and can be recalcitrant to conservative measures, which once exhausted may necessitate operative intervention. Blood and platelets, in particular, are a rich source of factors necessary for tissue healing. Autologous blood injections (ABI) are thought to promote tendon healing, but have been explored clinically in only a few limited studies. However, recently they have attracted media attention in relation to the world of professional athletes and sports-related injuries.

METHOD

We review the evidence base for this technique using the available literature on PubMed.

CONCLUSION

Refractory chronic tendinopathy may be responsive to ABIs, but the data available to date are limited by quality and size of study, as well as length of follow up, and are currently insufficient to recommend this modality for routine clinical use.

摘要

背景

慢性肌腱病是一种常见的致残原因,且对保守治疗措施有抗性,一旦保守治疗措施无效,可能需要手术干预。血液和血小板是组织愈合所需因子的丰富来源。自体血注射(ABI)被认为可以促进肌腱愈合,但在临床上仅在少数有限的研究中进行了探索。然而,最近它们因与职业运动员和与运动相关的损伤相关的世界而受到媒体关注。

方法

我们使用 PubMed 上的现有文献,回顾了该技术的证据基础。

结论

难治性慢性肌腱病可能对 ABI 有反应,但目前可用的数据受到研究质量和大小、随访时间的限制,目前不足以推荐该方法常规用于临床。

相似文献

1
Treatment of tendinopathy: is there a role for autologous whole blood and platelet rich plasma injection?治疗腱病:自体全血和富含血小板的血浆注射有作用吗?
Int J Clin Pract. 2010 Dec;64(13):1813-23. doi: 10.1111/j.1742-1241.2010.02432.x.
2
Autologous growth factor injections in chronic tendinopathy.自体生长因子注射治疗慢性肌腱病。
J Athl Train. 2014 May-Jun;49(3):428-30. doi: 10.4085/1062-6050-49.3.06. Epub 2014 May 19.
3
Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections.基于生长因子的治疗在抵抗性肘肌腱病的物理治疗之外提供了额外的益处:自体血注射与富含血小板的血浆注射的前瞻性、单盲、随机试验。
Br J Sports Med. 2011 Sep;45(12):966-71. doi: 10.1136/bjsm.2010.082503. Epub 2011 Mar 15.
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Platelet-rich plasma application in the management of chronic tendinopathies.富血小板血浆在慢性肌腱病管理中的应用。
Acta Orthop Belg. 2013 Feb;79(1):10-5.
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Sports medicine and platelet-rich plasma: nonsurgical therapy.运动医学与富血小板血浆:非手术治疗
Clin Podiatr Med Surg. 2015 Jan;32(1):99-107. doi: 10.1016/j.cpm.2014.09.006.
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Current concepts for the use of platelet-rich plasma in the foot and ankle.富血小板血浆在足踝部应用的当前概念
Clin Podiatr Med Surg. 2011 Jan;28(1):155-70. doi: 10.1016/j.cpm.2010.09.001.
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[Treatment of tendinopathies: role for autologous platelet-rich plasma injections].[肌腱病的治疗:富血小板血浆自体注射的作用]
Rev Med Suisse. 2011 Aug 10;7(304):1533-7.
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Autologous growth factor injections in chronic tendinopathy: a systematic review.自体生长因子注射治疗慢性肌腱病:系统评价。
Br Med Bull. 2010;95:63-77. doi: 10.1093/bmb/ldq006. Epub 2010 Mar 2.
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Platelet rich plasma. A new treatment tool for the rheumatologist?富含血小板血浆。风湿病学家的一种新治疗工具?
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Injectable agents derived from or targeting vascularity: has clinical acceptance in managing tendon disorders superseded scientific evidence?源自血管或靶向血管的注射剂:在治疗肌腱疾病方面的临床认可度是否已超越科学证据?
J Musculoskelet Neuronal Interact. 2011 Jun;11(2):174-84.

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