电刺激大鼠视前内侧区增加慢波睡眠

Glutamate microinjection at the medial preoptic area enhances slow wave sleep in rats.

机构信息

Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

出版信息

Behav Brain Res. 2011 Feb 2;217(1):240-3. doi: 10.1016/j.bbr.2010.11.007. Epub 2010 Nov 9.

DOI:10.1016/j.bbr.2010.11.007

Abstract

A large body of evidence has established the role of the medial preoptic area (mPOA) in regulation of slow wave sleep (SWS). Although the mPOA neurons contain excitatory neurotransmitter glutamate, its role in sleep-wakefulness is not known. In the present study microinjection of monosodium glutamate (40, 80 and 120 ng) into the mPOA augmented SWS. Earlier reports have shown enhancement of paradoxical sleep by glutamate in other brain areas.

摘要

大量证据已经确立了内侧视前区（mPOA）在调节慢波睡眠（SWS）中的作用。尽管 mPOA 神经元含有兴奋性神经递质谷氨酸，但它在睡眠-觉醒中的作用尚不清楚。在本研究中，将单谷氨酸钠（40、80 和 120ng）微注射到 mPOA 中增强了 SWS。早期的报告显示，谷氨酸在大脑的其他区域增强了反常睡眠。