睡眠与觉醒的神经药理学：2012年更新
Neuropharmacology of Sleep and Wakefulness: 2012 Update.
作者信息
Watson Christopher J, Baghdoyan Helen A, Lydic Ralph
机构信息
Department of Anesthesiology, University of Michigan, Ann Arbor, MI, U.S.A.
出版信息
Sleep Med Clin. 2012 Sep 1;7(3):469-486. doi: 10.1016/j.jsmc.2012.06.010. Epub 2012 Sep 4.
Abstract
The development of sedative/hypnotic molecules has been empiric rather than rational. The empiric approach has produced clinically useful drugs but for no drug is the mechanism of action completely understood. All available sedative/hypnotic medications have unwanted side effects and none of these medications creates a sleep architecture that is identical to the architecture of naturally occurring sleep. This chapter reviews recent advances in research aiming to elucidate the neurochemical mechanisms regulating sleep and wakefulness. One promise of rational drug design is that understanding the mechanisms of sedative/hypnotic action will significantly enhance drug safety and efficacy.
摘要
镇静/催眠分子的研发一直是凭经验而非基于理性。经验性方法已产生了临床上有用的药物，但没有一种药物的作用机制被完全理解。所有现有的镇静/催眠药物都有不良副作用，而且这些药物中没有一种能产生与自然睡眠结构完全相同的睡眠结构。本章回顾了旨在阐明调节睡眠和觉醒的神经化学机制的研究最新进展。理性药物设计的一个前景是，了解镇静/催眠作用机制将显著提高药物的安全性和疗效。
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