Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
JACC Cardiovasc Imaging. 2010 Nov;3(11):1158-65. doi: 10.1016/j.jcmg.2010.08.014.
Fast, minimally invasive, high-resolution intravascular imaging is essential for identifying vascular pathological features and for developing novel diagnostic tools and treatments. Intravascular magnetic resonance imaging (MRI) with active internal probes offers high sensitivity to pathological features without ionizing radiation or the limited luminal views of conventional X-rays, but has been unable to provide a high-speed, high-resolution, endoscopic view. Herein, real-time MRI endoscopy is introduced for performing MRI from a viewpoint intrinsically locked to a miniature active, internal transmitter-receiver in a clinical 3.0-T MRI scanner. Real-time MRI endoscopy at up to 2 frames/s depicts vascular wall morphological features, atherosclerosis, and calcification at 80 to 300 μm resolution during probe advancement through diseased human iliac artery specimens and atherosclerotic rabbit aortas in vivo. MRI endoscopy offers the potential for fast, minimally invasive, transluminal, high-resolution imaging of vascular disease on a common clinical platform suitable for evaluating and targeting atherosclerosis in both experimental and clinical settings.
快速、微创、高分辨率的血管内成像对于识别血管病理特征以及开发新的诊断工具和治疗方法至关重要。带有主动内部探头的血管内磁共振成像 (MRI) 具有对病理特征的高灵敏度，不会产生电离辐射，也不会受到传统 X 射线有限的管腔视野的限制，但一直无法提供高速、高分辨率的内窥视图。在此，引入了实时 MRI 内窥镜检查，以便在临床 3.0-T MRI 扫描仪中从与微型主动内部发射器-接收器内在锁定的角度进行 MRI 检查。实时 MRI 内窥镜检查最高可达 2 帧/秒，在通过患病的人类髂动脉标本和体内动脉粥样硬化兔主动脉推进探头时，以 80 至 300 μm 的分辨率描绘血管壁形态特征、动脉粥样硬化和钙化。MRI 内窥镜检查有可能在适合评估和靶向实验和临床环境中动脉粥样硬化的常见临床平台上，快速、微创、经腔、高分辨率地成像血管疾病。
