Miller D C, Koslow M, Budzilovich G N, Burstein D E
Rita and Stanley Kaplan Cancer Center, Department of Pathology, New York University Medical Center, NY 10016.
Hum Pathol. 1990 Mar;21(3):271-6. doi: 10.1016/0046-8177(90)90226-u.
Synaptophysin, a 38-kilodalton glycoprotein found in synaptic vesicle membranes, has been shown to be a sensitive marker of neuroendocrine differentiation in non-central nervous system (CNS) tumors. We analyzed the patterns of synaptophysin immunoreactivity in CNS neoplasms in comparison with various normal CNS sites in biopsies. Normal gray matter structures all showed a diffuse punctate granular pattern of neuropil staining without staining of neuronal cell bodies. In contrast, neoplastic ganglion cells in 18 of 18 gangliogliomas/gangliocytomas showed intense immunoreactivity outlining the borders of the cell bodies. Focal staining was also seen in five of 16 primitive neuroectodermal tumors and in one of three central neurocytomas, but these tumors had a finely granular neuropil pattern of immunoreactivity more like that of normal gray matter than like that of the gangliogliomas. All 35 examples of pure gliomas of various types showed no immunoreactivity. Our data highlight synaptophysin as a sensitive and specific marker of both neuronal lineage and neoplastic character in gangliogliomas.
突触素是一种存在于突触小泡膜中的38千道尔顿糖蛋白，已被证明是非中枢神经系统（CNS）肿瘤中神经内分泌分化的敏感标志物。我们分析了中枢神经系统肿瘤中突触素免疫反应性模式，并与活检中各种正常中枢神经系统部位进行了比较。正常灰质结构均显示神经毡弥漫性点状颗粒状染色模式，神经元细胞体无染色。相比之下，18例神经节胶质瘤/神经节细胞瘤中的18例肿瘤性神经节细胞显示出强烈的免疫反应性，勾勒出细胞体的边界。在16例原始神经外胚层肿瘤中的5例以及3例中枢神经细胞瘤中的1例中也可见局灶性染色，但这些肿瘤的免疫反应性呈细颗粒状神经毡模式，更类似于正常灰质而非神经节胶质瘤。35例各种类型的纯胶质瘤均未显示免疫反应性。我们的数据突出了突触素作为神经节胶质瘤中神经元谱系和肿瘤特征的敏感和特异性标志物。
