Instituto Cajal, CSIC, Avenida Doctor Arce 37, E-28002 Madrid, Spain.
J Mol Endocrinol. 2011 Jan 19;46(1):R1-9. doi: 10.1677/JME-10-0122. Print 2011 Feb.
Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.
选择性雌激素受体调节剂（SERMs），用于治疗乳腺癌、骨质疏松症和更年期症状，会影响神经系统。一些 SERMs 触发神经保护机制，并减少不同神经创伤、脑炎症、神经退行性疾病、认知障碍和情感障碍的实验模型中的神经损伤。具有神经元和神经胶质细胞特定作用的新型 SERMs 可能是治疗大脑的有前途的治疗工具。
