Yamaga Yuichi, Ohana Masaya, Nakamura Takefumi, Kikuchi Shino, Matsumura Kayoko, Takita Masahiro, Iwamoto Satoru, Morisawa Toshiyuki, Miyajima Shinji, Kida Hajime, Okano Akihiro, Okinaga Satoshi, Kusumi Fusako, Takakuwa Hiroshi, Honjou Gen
Department of Gastroenterology and Hepatology, Tenri Hospital.
Nihon Shokakibyo Gakkai Zasshi. 2010 Nov;107(11):1806-13.
A 50-year-old woman was admitted to our hospital because of abdominal pain and vomiting. Ileus with ulcerated jejunal tumor was diagnosed and biopsy revealed adenocarcinoma. Because her serum level of DUPAN-2 was high, she was examined by PET scan, which revealed that she had a left ovarian mass in addition to the jejunal tumor. Surgical resection was performed: both tumors were adenocarcinoma, but the ovarian tumor was considered to be metastatic clinically and histologically. Immunostaining for DUPAN-2 was positive in the both tumors. The serum level of DUPAN-2 returned to normal after the surgery, and has been within normal limits for about 3 years without any additional therapy. This case shows a possible relation between small bowel adenocarcinoma and DUPAN-2.
一名50岁女性因腹痛和呕吐入院。诊断为肠梗阻伴空肠肿瘤溃疡，活检显示为腺癌。由于她的DUPAN-2血清水平较高，遂进行了PET扫描检查，结果显示除空肠肿瘤外，她还有左侧卵巢肿块。进行了手术切除：两个肿瘤均为腺癌，但卵巢肿瘤在临床和组织学上被认为是转移性的。两个肿瘤的DUPAN-2免疫染色均为阳性。术后DUPAN-2血清水平恢复正常，在未进行任何额外治疗的情况下，已保持在正常范围内约3年。该病例显示了小肠腺癌与DUPAN-2之间可能存在的关联。
