Department of Biology and Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA.
Metallomics. 2010 Nov;2(11):732-40. doi: 10.1039/c0mt00023j. Epub 2010 Sep 24.
Excessive or misplaced tissue iron now is recognized to pose a substantial health risk for an extensive array of endocrinological, gastrointestinal, infectious, neoplasmic, neurodegenerative, obstetric, ophthalmic, orthopedic, pulmonary and vascular diseases. Ingested, injected, inhaled and decompartmentalized iron contributes not only to disease, but also to aging and mortality. Iron is dangerous by catalyzing free radical formation and by serving as an essential nutrient for microbial and neoplasmic cell invaders. Our body cells exhibit wide variation in sensitivity to iron toxicity. Efficacy of our iron withholding defense system is modulated by numerous environmental, behavioral and genetic factors. A notable variety of methods for prevention and therapy of iron toxicity are now becoming available.
目前，人们认识到过多或错位的组织铁对广泛的内分泌、胃肠道、传染病、肿瘤、神经退行性、产科、眼科、骨科、肺部和血管疾病构成了重大健康风险。摄入、注射、吸入和隔室化的铁不仅导致疾病，还导致衰老和死亡。铁通过催化自由基形成和作为微生物和肿瘤细胞入侵的必需营养素而变得危险。我们的体细胞对铁毒性的敏感性差异很大。我们的铁扣留防御系统的功效受到许多环境、行为和遗传因素的调节。现在有许多种预防和治疗铁毒性的方法。
