Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK.
Metallomics. 2010 Jun;2(6):397-9. doi: 10.1039/c004952b. Epub 2010 May 20.
2-Oxoglutarate oxygenases are inhibited by a range of transition metals, as exemplified by studies on human histone demethylases and prolyl hydroxylase domain 2 (PHD2 or EGLN1). The biological effects associated with 2-oxoglutarate oxygenase inhibition may result from inhibition of more than one enzyme and by mechanisms in addition to simple competition with the Fe(ii) cofactor.
2- 氧戊二酸氧酶受一系列过渡金属的抑制，人类组蛋白去甲基酶和脯氨酰羟化酶结构域 2（PHD2 或 EGLN1）的研究即为典型例证。与 2- 氧戊二酸氧酶抑制相关的生物学效应可能源于对不止一种酶的抑制，并且除了与 Fe（ii）辅因子的简单竞争之外，还存在其他机制。
