2- 氧戊二酸氧酶被一系列过渡金属所抑制。
2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
机构信息
Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK.
出版信息
Metallomics. 2010 Jun;2(6):397-9. doi: 10.1039/c004952b. Epub 2010 May 20.
DOI:10.1039/c004952b
PMID:21072385
Abstract
2-Oxoglutarate oxygenases are inhibited by a range of transition metals, as exemplified by studies on human histone demethylases and prolyl hydroxylase domain 2 (PHD2 or EGLN1). The biological effects associated with 2-oxoglutarate oxygenase inhibition may result from inhibition of more than one enzyme and by mechanisms in addition to simple competition with the Fe(ii) cofactor.
摘要
2- 氧戊二酸氧酶受一系列过渡金属的抑制，人类组蛋白去甲基酶和脯氨酰羟化酶结构域 2（PHD2 或 EGLN1）的研究即为典型例证。与 2- 氧戊二酸氧酶抑制相关的生物学效应可能源于对不止一种酶的抑制，并且除了与 Fe（ii）辅因子的简单竞争之外，还存在其他机制。
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