Centro de Biomateriales e Ingeniería Tisular, Universidad Politécnica de Valencia, Valencia, Spain.
J Mater Sci Mater Med. 2011 Jan;22(1):11-8. doi: 10.1007/s10856-010-4182-6. Epub 2010 Nov 12.
Alkaline hydrolysis of a polycaprolactone (PCL) network obtained by photopolymerization of a PCL macromer was investigated. The PCL macromer was obtained by the reaction of PCL diol with methacrylic anhydride. Degradation of PCL network is much faster than linear PCL; the weight loss rate is approximately constant until it reaches around 70%, which happens after approximately 60 h in PCL network and 600 h in linear PCL. Calorimetric results show no changes in crystallinity throughout degradation, suggesting that it takes place in the crystalline and amorphous phases simultaneously. Scanning electron microscopy microphotographs indicate that degradation is produced by a different erosion mechanism in both kinds of samples. The more hydrophilic network PCL would follow a bulk-erosion mechanism, whereas linear PCL would follow a surface-erosion mechanism. Mechanical testing of degraded samples shows a decline in mechanical properties due to changes in sample porosity as a consequence of the degradation process.
通过光聚合聚己内酯（PCL）大分子单体得到的 PCL 网络的碱性水解得到了研究。PCL 大分子单体是通过 PCL 二醇与甲基丙烯酰酐的反应获得的。PCL 网络的降解速度比线性 PCL 快得多；在大约 70%的重量损失率之前，其降解速度几乎保持不变，在 PCL 网络中大约需要 60 小时，在线性 PCL 中大约需要 600 小时。量热结果表明在整个降解过程中结晶度没有变化，这表明它同时发生在结晶相和非晶相。扫描电子显微镜微观照片表明，在这两种类型的样品中，降解是由不同的侵蚀机制产生的。亲水性更强的网络 PCL 将遵循体侵蚀机制，而线性 PCL 将遵循表面侵蚀机制。降解样品的机械性能测试表明，由于降解过程中样品孔隙率的变化，机械性能下降。
