Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, 46022, Valencia, Spain.
J Mater Sci Mater Med. 2012 Jul;23(7):1605-17. doi: 10.1007/s10856-012-4649-8. Epub 2012 Apr 26.
Copolymer networks from poly(ethylene glycol) methacrylate (PEGMA) and caprolactone 2-(methacryloyloxy) ethyl ester were synthesized and the resulting structure of the copolymer network was characterized by differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, equilibrium water gain and dynamic mechanical analysis, results which were employed to conclude about the network structure of the resulting copolymers. The new material is a random copolymer with a good miscibility and increasing hydrophilicity as the PEGMA content increases in the composition. Physical data suggest an excess free volume and synergistic interactions between the lateral chains of both comonomers. Olfactory ensheathing cells were cultured on the different networks, and cell viability and proliferation were assessed by MTS assay. The copolymers with a 30 wt% of PEGMA showed the best results compared with the other compositions in this respect, indicating the relevance for biological performance of a balance of hydrophilic and hydrophobic functionalities in the polymer chain.
聚(乙二醇)甲基丙烯酸酯(PEGMA)和己内酯 2-(甲基丙烯酰氧基)乙酯的共聚物网络被合成，共聚物网络的结构通过差示扫描量热法、热重分析、傅里叶变换红外光谱、平衡水吸收和动态力学分析进行了表征，结果用于推断所得共聚物的网络结构。这种新材料是一种随机共聚物，随着组成中 PEGMA 含量的增加，具有良好的混溶性和增加的亲水性。物理数据表明，在两种单体的侧链之间存在过剩的自由体积和协同相互作用。不同的网络上培养嗅鞘细胞，通过 MTS 测定法评估细胞活力和增殖。与其他组成相比，PEGMA 含量为 30wt%的共聚物在这方面表现出最好的结果，这表明在聚合物链中平衡亲水和疏水官能团对于生物性能的相关性。
