Sood S K, Ballanco G A, Mather F J, Pramberg J C, Daum R S
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112.
J Infect Dis. 1990 Mar;161(3):574-7. doi: 10.1093/infdis/161.3.574.
The occurrence of Haemophilus influenzae type b capsular polysaccharide antigenemia and antigenuria following immunization was studied in 48 healthy 2-month-old infants. Each received a conjugate vaccine consisting of H. influenzae type b capsular polysaccharide covalently linked to Neisseria meningitidis serotype b outer membrane protein at 2 and 4 months of age. Infants were alternated at enrollment for collection of blood and urine after either the first or second dose. Specimens were obtained "early" (2-3 days) after immunization and "late" (7 days) after immunization and assayed for antigen. Antigen was detected in the serum of 3 (6%) of 48 infants, uniformly in the "early" specimen obtained after the first dose of vaccine. Antigenuria occurred in 37 (80%) of 46 infants; for greater than or equal to 7 days in 12 (26%). Antigenuria was frequent after administration of the vaccine but antigenemia was not. These data should be considered in the evaluation of an infant with suspected H. influenzae type b invasive disease.
对48名健康的2个月大婴儿进行了研究，以观察接种疫苗后b型流感嗜血杆菌荚膜多糖抗原血症和抗原尿的发生情况。每名婴儿在2个月和4个月大时接种了一种结合疫苗，该疫苗由与b型脑膜炎奈瑟菌外膜蛋白共价连接的b型流感嗜血杆菌荚膜多糖组成。婴儿在入组时交替安排在接种第一剂或第二剂疫苗后采集血液和尿液。在免疫“早期”（2 - 3天）和免疫“晚期”（7天）采集标本并检测抗原。在48名婴儿中的3名（6%）血清中检测到抗原，均在接种第一剂疫苗后获得的“早期”标本中。46名婴儿中有37名（80%）出现抗原尿；12名（26%）持续≥7天。接种疫苗后抗原尿很常见，但抗原血症不常见。在评估疑似b型流感嗜血杆菌侵袭性疾病的婴儿时应考虑这些数据。
