The K+-dependent phosphatase from human renal tissue: its properties and time dependent inhibition by ouabain.
作者信息
Braughler J M, Corder C N
出版信息
Arch Int Pharmacodyn Ther. 1978 Jun;233(2):192-9.
PMID:210729
Abstract
The K+-dependent p-nitrophenyl phosphatase activity associated with human renal (Na+ + K+)-ATPase was examined for some of its kinetic properties. ATP inhibited the K+-dependent phosphatase and raised the Km for p-nitrophenylphosphate. Stimulation of the K+-dependent phosphatase by K+ was blocked by Na+ in a noncompetitive manner. Inhibition of the K+-dependent phosphatase by ouabain was dependent upon incubation time. The apparent Kï was 2.0 micron.
摘要
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