Valentino Biagio, Peri Giovanni, Lipari Luana, Valentino Alessandro, Cappello Francesco, Lipari Elvira Farina
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, University of Palermo, Italy.
Ital J Anat Embryol. 2010;115(1-2):159-65.
Atrial natriuretic peptide, oxytocin and vasopressin are three well known and widely studied molecules since many years. They have been fully characterised from a genetic and biomolecular point of view and a number of receptor-dependent functions have been recognised for them. Nevertheless, in the last years our group has conducted morphologic studies, using an immunohistochemical approach complemented by molecular biology techniques, and could show non-canonical localization and co-localization of these peptides in normal and pathologic tissues, that permitted us to postulate that they may be involved in a wider range of functions than usually assumed and not yet fully understood. In this minireview we summarise some of the main results that open new scenarios in the comprehension of the biologic activities of these peptides and allow to postulate a role for them as diagnostic tools.
多年来，心房利钠肽、催产素和血管加压素是三种广为人知且被广泛研究的分子。从基因和生物分子角度来看，它们已被充分表征，并且已认识到它们具有许多依赖受体的功能。然而，在过去几年中，我们团队采用免疫组织化学方法并辅以分子生物学技术进行了形态学研究，结果表明这些肽在正常和病理组织中存在非经典定位和共定位，这使我们推测它们可能参与比通常认为的更广泛且尚未完全理解的功能。在这篇迷你综述中，我们总结了一些主要结果，这些结果为理解这些肽的生物活性开辟了新的前景，并使我们能够推测它们作为诊断工具的作用。
